Est! Est!! Est!!! and Frascati are the wines of choice. And you can see the mighty façade of the Colosseum right from Palazzo Manfredi's fifth-story garden-terrace restaurant, Aroma, as you wolf down that gnocchetti with black truffle. At the Galleria Borghese you'll see the Baroque art of Caravaggio and Bernini, and at the Vatican, if you stand beneath the dome of the Sistine Chapel and look up, you'll see Michelangelo's cherubs and apostles. Cool stuff!